Aiming Liu Selected Research

Gemfibrozil (Lopid)

12/2017	Species-related exposure of phase II metabolite gemfibrozil 1-O-β-glucuronide between human and mice: A net induction of mouse P450 activity was revealed.
2/2017	PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate.
4/2016	Gemfibrozil not fenofibrate decreases systemic glucose level via PPARα.
4/2014	Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity.
2/2011	Biphasic regulation of intracellular calcium by gemfibrozil contributes to inhibiting L6 myoblast differentiation: implications for clinical myotoxicity.
1/2011	Induction of P450 3A1/2 and 2C6 by gemfibrozil in Sprague-Dawley rats.
3/2009	Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties.

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Aiming Liu Research Topics

Disease

8	Dyslipidemias (Dyslipidemia) 12/2017 - 03/2009
7	Cholestasis 01/2021 - 09/2016
5	Liver Diseases (Liver Disease) 08/2020 - 11/2014
4	Inflammation (Inflammations) 12/2020 - 02/2017
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2018 - 04/2016
3	Intrahepatic Cholestasis 09/2017 - 01/2016
3	Myotoxicity 02/2011 - 03/2009
2	Obesity 01/2020 - 12/2018
2	Hepatomegaly 01/2019 - 02/2017
2	Atherosclerosis 12/2017 - 03/2012
2	Alzheimer Disease (Alzheimer's Disease) 01/2016 - 08/2013
2	Memory Disorders (Memory Loss) 01/2016 - 08/2013
1	Non-alcoholic Fatty Liver Disease 01/2022
1	Hyperlipidemias (Hyperlipidemia) 01/2022
1	Thrombosis (Thrombus) 01/2022
1	Hemorrhage 04/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021
1	Asthma (Bronchial Asthma) 01/2021
1	Septic Shock (Toxic Shock Syndrome) 10/2020
1	Shock 10/2020
1	Weight Gain 01/2020
1	Hypertension (High Blood Pressure) 12/2018
1	Insulin Resistance 12/2018
1	Sclerosing Cholangitis 09/2017
1	Metabolic Diseases (Metabolic Disease) 09/2017
1	Edema (Dropsy) 01/2017
1	Necrosis 09/2016
1	Wounds and Injuries (Trauma) 01/2016
1	Jaundice (Icterus) 01/2016
1	Cognitive Dysfunction 01/2016
1	Cardiotoxicity 05/2015
1	Obstructive Jaundice (Cholestatic Jaundice) 04/2014
1	Cholelithiasis 04/2014
1	Neuroinflammatory Diseases 08/2013
1	Carcinogenesis 06/2013
1	Torsades de Pointes (Torsade de Pointes) 10/2012
1	Gastroenteritis 05/2012
1	Liver Neoplasms (Liver Cancer) 06/2009
1	Neoplasms (Cancer) 06/2009

Drug/Important Bio-Agent (IBA)

10	Fibric Acids (Fibrates)IBA 12/2018 - 03/2009
7	Fenofibrate (CiL)FDA LinkGeneric 01/2021 - 06/2009
7	Gemfibrozil (Lopid)FDA LinkGeneric 12/2017 - 03/2009
6	Pharmaceutical PreparationsIBA 12/2017 - 03/2009
5	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2022 - 01/2011
4	PPAR alphaIBA 01/2021 - 03/2009
2	LipidsIBA 01/2022 - 01/2020
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2020
2	1-Naphthylisothiocyanate (1 Naphthylisothiocyanate)IBA 01/2021 - 01/2016
2	pyrazolanthroneIBA 12/2020 - 09/2017
2	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 08/2020 - 01/2017
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2019 - 06/2009
2	Bile Acids and Salts (Bile Acids)IBA 01/2019 - 02/2017
2	CalciumIBA 03/2012 - 02/2011
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2022
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022
1	NF-kappa B (NF-kB)IBA 01/2022
1	Proton Pump InhibitorsIBA 04/2021
1	Air Pollutants (Pollutants, Air)IBA 01/2021
1	Human Serum Albumin FDA LinkGeneric 10/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 10/2020
1	AcidsIBA 10/2020
1	XenobioticsIBA 01/2019
1	Pregnane X ReceptorIBA 01/2019
1	Triglycerides (Triacylglycerol)IBA 12/2018
1	HDL LipoproteinsIBA 12/2018
1	Interleukin-10 (Interleukin 10)IBA 02/2017
1	schizandrol BIBA 01/2017
1	obeticholic acidIBA 01/2017
1	Lithocholic AcidIBA 01/2017
1	CytokinesIBA 09/2016
1	Chlorogenic AcidIBA 09/2016
1	Interleukin-6 (Interleukin 6)IBA 09/2016
1	GlycogenIBA 04/2016
1	Glucose (Dextrose)FDA LinkGeneric 04/2016
1	yin zhi huangIBA 01/2016
1	Atorvastatin (Lipitor)FDA Link 01/2016
1	geniposideIBA 01/2016
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2016
1	AlkaloidsIBA 05/2015
1	Silver Sulfadiazine (SSD)FDA LinkGeneric 11/2014
1	saikosaponin DIBA 11/2014
1	LigandsIBA 04/2014
1	Amyloid beta-PeptidesIBA 08/2013
1	Peptides (Polypeptides)IBA 08/2013
1	Cyclic GMPIBA 08/2013
1	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 08/2013
1	Amyloid (Amyloid Fibrils)IBA 08/2013
1	Sildenafil Citrate (Viagra)FDA Link 08/2013
1	BerberineIBA 05/2012

Therapy/Procedure

1	Injections 12/2020
1	Resuscitation 10/2020
1	Therapeutics 08/2020
1	Oral Administration 01/2017